I'm speaking in general terms,  there are some rifles and calibers that can shoot different bullet styles and grain weights to roughly the same point of impact with at least decent accuracy.  Other rifles can be finiky at best regardless of ammo tested this is the beauty of handloading.  Some people don't have the inclination, time, money, or need to handload and that's not a bad thing we all have different needs.  Partitions and I use a lot of them are not always the most accurate,   I'm splitting hairs here most of the time I'm happy with a consistant 1 inch 5 shot group with partitions as a whole,  some will shoot 3/4 "  no problem, where as the same rifle with known accuracy bullets will shoot 1/2 " groups.  The hunting accuracy difference isn't that huge.  The main reason partitions aren't considered match accuracy bullets is the design,  you are sticking a hunk of lead in one end and a piece of lead in the other with an H section in between.  This doesn't lend itself to a perfectly balanced bullet all things being equal.  Bearing surface, bullet boat tail or non boat tail,  bullet length,  velocity all can play parts in  accuracy.  Jacket thickness,  how precise the bullets are actually made,  bullet tip deformation can affect accuracy,  to what point and degree is dependent on the  rifle,  the loads, etc.  If you know your rifles don't like the 150's don't shoot them and stick with what works.  If you are hand loading you have options of fine tuning.  Personally  I really don't see a reason to use a 150 in a 300 wby,  your 180's even 165's are probably better for hunting anyway.  I don't think even Nosler custom ammo lists a 150 partition in the 300 wby where they list  150 accubond,  why I don't know they would load one but not the other,  probably not a big seller.   You are going to find guy's who use lighter than 150's in a 300 wby and  likelty 99 percent are handloaders.  Is it wrong for them to use these bullets ?  No,  they found something they like  that's what they use and more power to them for it.  What I don't understand is you have several 300 wby's and none shoot 150 partitions, I don't get that one at all, unless you are expecting pinpoint accuracy across the board.