Roger, thats an interesting little package with a big wallop. If you don't already have a thumper in a lever gun, or in an AR, and since bolt actions are suppose to be a more accurate platform, (debatable) the Ruger is probably a good choice. The suggested usage for the 450 says med/Lg. where the Weatherby 240 is rated for med. only. (some hunters are known to extend the 240's capabilities) Neither cal. has a big selection of factory loads. I guess your intended use of the rifle has a lot to do with your final choice, so that may carry more weight. I did notice on the Hornady ballistics that for a 200 yard zero, you would be 4.9 inches high at 100yards. Thats probably common for "big bore" so to speak calibers in lever and the AR platform though. So do you want to hit your target with a marble or a bowling ball? Ha Ha Buying a new rifle is always fun, so good luck in buying what you want.