Late to the game on this one griz, but i've actually booked a predator hunt with these guys i use. My #1 goal is to come away with a cat I can mount, first rattle out of the box they said bring a shotgun. They told me they would bring 12ga shells, not sure what kind at this moment. But he said I shoot 22-250 and 12ga, 90 percent of them get shot with shotgun in his sets. I found some 62 grain bear claw bullets i'm going to load for the 22-250 can also use them in 220 swift i have for hogs, deer and other stuff. But i figured a good non fragmenting bullet would be best myself.
My only real world experience has been small grey fox's which we have plenty off at our ranch. Shooting 204 vmax tears them up pretty good, shoot some bergers and did much better. Go figure -