The big bores I plan to own are the .375H&H, .416 Rigby, .458 Lott. (id pick one of these 3 and never look back,decide which bore you want and pick one of these 3, case closed) and I'd want it with a controlled feed action, ie model 70, mauser 98 claw style, winchester, ruger, cz, etc...
If you really wanted a weatherby big bore I'd get the .416 wby.. oh and I'd never own another rifle with a muzzle brake, so I'd skip the .416wby and one of the ones above I mentioned.