Where I live, the 22lr makes sense for smaller stuff, I'd prefer the 223 for predators, the 7mm-08 or 30-06 for a middle caliber and definitely the 338 WM for everything Alaska has to offer. I've owned a 375 H&H and don't like the long action and the weight associated with rifles chambered for it. The 375 Ruger is interesting but I see it as unnecessary for everything but big bears. The 338 WM has filled the "Sitka Blacktails to Brown Bears" niche very nicely for me since 1993.