I load for the .338-.378 and use 112 grains of RL 25 with a Federal 215 Match primer and the 200 grain Nosler Balistic Tips.  Unfortunately Nosler decided to drop the Balistic Tips for the .338 and reintroduced them in the Accubonds.  This is a wonderful load, can consistantly put 5 shots touching at 100 yards with out even trying.  Nosler claims that the Accubonds and Balistic Tips "should shoot exactly the same and not need any sight adjustment" but we will see.  For what I do with mine, shooting white tail deer, black bear, and targets, I really don't need to use the Accubonds or spend the extra money but Nosler took care of that by eliminating the Balistic Tips, which ran about $15- $20 a box of 50, and are only selling the Accubonds, which run from $28-$35 a box of 50 depending on where you get them.  I will be the first to tell anyone at less than 150 yards go for the neck, unless you want a big hole in your deer, after 150 the bullet "calms down" enough to go for a behind the shoulder shot.  One other bit of advice I have is put a disposable ear plug in your ear that is closest to the muzzle, namely left if your a right handed shooter or the right if left handed, because of the great muzzle blast.