Out to 300-400yds, you don't really see any advantage to the VLD profile. Trajectory doesn't start to really open up until after 400, and in some chamberings, well after.
What bullets would I consider for your criteria of up close to 400yds, for Mule Deer? I'll make some assumptions that with Muleys in mind, the 165gr is a viable weight class. That said, I'd strongly consider the Nosler E-Tip, Partition, or Accubond, the Hornady Interbond or GMX, the Barnes TTSX, the Swift Scirocco or A-Frame, or even the Speer Grand Slam. Any of these is going to be good up close and still good out to 400yds. With the monoliths, velocity will still be around 2400fps, which I suspect is ample to open up on a Muley. The monoliths will certainly hold together well at close range without blowing apart, also.
With a 165gr at 3200fps (very achievable in the 300WinMag) you could set it up with a 2.5" peak trajectory above point of aim, and have somewhere around 290-300yds of point blank range with no holdover. At 400, drop is likely to be roughly a foot or so, meaning you'd hold right on the top line of the deer's back and hit right in the middle of the vitals. 350yds would just about split the difference between "hold dead on" and "hold top of back" and you'd be well handled all the way out to 400. That's a match made in heaven.