I love shooting targets at long range, but the bullet's time-to-target makes shooting at game seem irresponsible to me. It requires over a second, almost 1.5 seconds for my bullet to arrive at 1000 yards, and I believe that gives an animal way too much time to move before my bullet gets there, so even if my shot was as perfect as humanly possible, the animal may be injured and lost or even missed completely. Only under the most dire circumstances is that acceptable to me.
I do not doubt one's ability to shoot quite accurately at that distance, but I recognize the great ability of the game to move quickly. That makes long range hunting distasteful to me.