I've used a LH Accumark in 257 Wby Mag for quite a few years, I call this rifle The Roy. I'm firmly of the opinion that the 110 grain Accubond is THE bullet for the 257 Roy. Early on I worked up a handload that duplicates the factory load. My Accumark is not surprisingly very accurate, no problem delivering sub-MOA with both the factory 110 Accubond and my handload with the same bullet.
I have lived & hunted in North Dakota since the early 80s. Hunting big prairie whitetails, Badlands mulies, antelope, and coyotes requires a rifle that is accurate and flat shooting as shots tend to be long. I used many different calibers & rifles up here and until I got my 257Wby I was of the opinion that the 270 Winchester was the best round for ND and my customized LH Remington 700 SS was the best rifle to fire it from. After taking several deer with The Roy in 257 Wby, I decided that if I could only use one of the rifles for deer & goats in ND, I would have to go with the Roy.
As an aside, the 257 Wby is a superb long range coyote round. Early on, I worked up a load with the 85 grain Ballistic Tip and re-sighted with it after deer season. Ultimately I decided there was no need to do this as the 110 grain Accubond load is extremely accurate, flat shooting, bucked the wind better (we have lots of wind up here), and did less fur damage. It is almost easy to kill coyotes at 400 yards with this rifle & caliber combo...