I am sure I'll catch some grief but i currently use my 30-378 with 210gr bergers due to switching my mindset to more of a 2 rifle set up, using the 30-378 for EVERYTHING colorado and below and a 375 for everything above colorado. What I've used in the past was a 270 Ackley improved with various 140 and 150 grain pills and a 7mm rem mag with 175 and 180 grain pills.
Update: 257 Wby with 100 grain Swift Scirocco II. Dead right there.