We have been doing this for years, I normally will aim for a Heart / Lung shot not as much meat damage, with a couple exceptions I will aim for a shoulder, really long shots , and shot where the animal will drop down a canyon where I don't want to go haul them out and easier to find. Where I do have an issue is bullet selection when hunting Elk I've had bullets blow up on the shoulder and not penetrate and off to the races, so if you are going to intentionally hit a shoulder on a big animal make sure the bullet will go thru.