Having shot only one coyote with my .257 to date, at night at 50 yards, I don't have a vast experience base to draw upon. But I can report that the coyote was not turned inside out. There were simply two clean holes, entry and exit, and not much pelt damage, using the 100-grain factory load. I don't plan to make a habit out of it, as the .257 is now dedicated to shooting 120-grain loads at larger critters, a task at which it excels. I now have a dedicated 22-250 rig for coyotes and other predators. In the two short years I've owned my .257, it has, to date, tallied an impressive collection of one-shot kills, including 2 mule deer, 4 whitetail deer (including a 230-lb. 11 point bruiser), 1 pronghorn at 304 yards, 1 250-lb wild boar, 1 big javelina -- and the aforementioned unfortunate coyote.