150 g if it's calm 180 g if it's windy.
Like I posted earlier, when I started hunting I only had one rifle, a .30-06, and I worked up a 150 g load for deer and a 180 g load for elk.
Since pronghorn antelope season was ahead of deer and elk seasons, I would sight my rifle in with the 150 g bullets and go antelope hunting. Then I would re-sight with 180 g for elk, then re-sight again for deer.
Then I would be hunting deer with 150s and run into an elk, and shoot him with the 150. Or I would be hunting elk with the 180s and shoot a deer. Both worked, but it was a royal PITA changing bullet zeros every other week.
As I later got more rifles, I began to just zero each rifle to one bullet, and match the rifle to the animal that I would be hunting. Then one year I took my .257 Ackley with 117 g Sierra GameKing bullets on a Montana unlimited tag Bighorn sheep area and the last day out this heavy, ivory tipped, dark antlered 6x6 bull elk came walking about 75 yards from me and ...
When I first got my .300 Wby I loaded it with 168 g Barnes TSX bullets and it worked great on Texas exotics, Montana bull elk, and a variety of South African antelope from a 30 pound Klipspringer to a 500+ pound Sable.
Then I switched to 168 g Barnes TTSX bullets in my .300 Wby, and they worked great on Montana bull elk, a variety of New Zealand animals from a fallow deer to a red deer stag, and in Mozambique from 40 pound duiker antelope to a leopard and another 500+ pound Sable antelope.
I have now switched to Barnes 180 g TTSX bullets in my .300 Wby, and I have absolutely no doubt that they will work great on any North American animal from pronghorn antelope to moose.