in my opinion a .204-224Wby wouldn't last long.
most people think of their rifles as tools, and they won't buy a MkV when they get almost the same package in a 700 SPS for 500$.
just look at the .224 Wby Mag vs .22-250.
and frankly, if you can't hit it with 4200fs, you probably won't hit it with 4600fs.